• Jesse Eisenberg as Blu
  • Anne Hathaway as Jewel
  • Elijah Wood as Yin/ The Claw Twin 1
  • Joseph Gordon-Levitt as Yang/ The Claw Twin 2
  • Robert Downey, Jr. as Sherlock Holmes
  • Cate Blanchett as Rachel
  • George Lopez as Rafael
  • as Pedro
  • Jamie Foxx as Nico
  • Tracy Morgan as Luiz
  • Jack Black as Sam
  • Simon Pegg as Professor Liziarty
  • Gary Oldman as Lord Hellskull
  • Jude Law as Sir Arthur Conan Doyle/ Watson
  • Ryan Reynolds as Akato's decoy
  • Bill Nighy as Drake/ Akato
  • Chow Yun-Fat as Master Lee
  • Ben Affleck as Young Lee
  • Jackie Chan as Master Shin

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